Search results for "Significance analysis of microarrays"

showing 3 items of 3 documents

Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma

2014

Objectives: Early detection and treatment of an oral squamous cell carcinoma (OSCC) is critical because of its rapid growth, frequent lymph-node metastasis, and poor prognosis. However, no clinically-valuable methods of early diagnosis exist, and genetic analysis of OSCCs has yielded no biomarkers. Study Design: We investigated the expression of genes associated with inflammation in OSCCs via a quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) analysis of microarray data. Tumor and normal tissues from five patients with an OSCC were used for microarray analysis. Differentially-expressed genes, identified using permutation, local pooled error (LPE), t-tests, and signific…

MalePathologymedicine.medical_specialtyOdontologíaBiologyGenetic analysislaw.inventionMetastasislawGene expressionmedicineBiomarkers TumorHumansGeneral DentistryGenePolymerase chain reactionEarly Detection of CancerOral Medicine and PathologyMicroarray analysis techniquesGene Expression ProfilingResearchDNA NeoplasmMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludGene Expression Regulation Neoplasticstomatognathic diseasesOtorhinolaryngologyGenetic markerSignificance analysis of microarraysUNESCO::CIENCIAS MÉDICASCancer researchCarcinoma Squamous CellSurgeryFemaleMouth Neoplasms
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Abstract P2-05-04: Gene expression associated with poor prognosis of young TNBC patients

2015

Abstract Background: Among TNBC patients those of very young age (<40 years) display a significantly worse prognosis (Liedtke et al. 2013 Breast Cancer Res Treat). We verified this result in 1161 TNBC samples with full Affymetrix gene expression data of which 845 patients had both detailed age and follow up information. Materials and Methods: We split the full sample set into a finding cohort of 394 TNBC and a validation cohort of 767 TNBC encompassing 309 and 536 samples, respectively, with both age and follow up data. We then used significance analysis of microarrays (SAM) in the finding cohort to look for genes whose expression is associated with young age (<40 years). Iden…

OncologyCancer Researchmedicine.medical_specialtyPoor prognosisbusiness.industryCancermedicine.diseaseFull sampleYoung ageBreast cancerOncologyInternal medicineImmunologyGene expressionCohortSignificance analysis of microarraysmedicinebusinessCancer Research
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Gene Expression Profile of Chronic Myeloid Leukemia Innately Resistant to Imatinib

2007

Background. Most chronic myeloid leukemia patients who receive imatinib as first line-terapy will obtain, after 12 months treatment, complete cytogenetic and molecular response . However several cases will not achieve molecular response, but their innate mechanism(s) of resistance remain poorly understood. We tried to explore the molecular events involved in innate resistance in CML. Study design. Five patients who were molecular “non responder” and seven “major” responder were investigated by using the expression profile of a set of 380 genes. Multiple testing procedure (MTP), Significance Analysis of Microarrays (SAM), Empirical Bayes Analysis of Microarrays (EBAM), False Discovery Rate (…

business.industryMyeloid leukemiaImatinibGeneral MedicineCell cycleMolecular ResponseImmunologySignificance analysis of microarraysCancer researchmedicineEpigeneticsDNA microarraybusinessGenemedicine.drugClinical Leukemia
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